Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer
Y. Seo, S. Zhang, J. Jang, K.-P. Ko, K.-B. Kim, Y. Huang, D.-W. Kim, B. Kim, G. Zou, J. Zhang, S. Jun, W. Chu, N. A. Kirk, Y. E. Hwang, Y. H. Ban, , J.-I. Park
This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.
bioRxiv · Feb 15, 2023Cancer Biology