Y. Seo

IgG hexamers initiate acute lung injury

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.

Glucose-fed microbiota alters intestinal epithelium and increases susceptibility to bacterial pathogens

This study shows that a glucose-fed microbiota in C. elegans reduces lifespan and healthspan, increases intestinal permeability, and raises susceptibility to bacterial pathogens.

Nutlin-3a induced KRAS mutant lung cancer specific methuosis-like cell death is dependent on GFPT2

The paper shows that nutlin-3a induces methuosis-like cell death in KRAS mutant NSCLC cells dependent on GFPT2.

The adiponectin analogue ALY688-SR attenuates diaphragm fibrosis, atrophy and mitochondrial stress in a mouse model of Duchenne muscular dystrophy

This paper shows that ALY688-SR reduces diaphragm fibrosis and atrophy in DMD mice by lowering mitochondrial stress, but not in tibialis anterior.

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

Optimizing anesthesia and delivery approaches for dosing into lungs of mice

This study compares pulmonary dosing efficiency in mice under different anesthetic and delivery methods, finding that ketamine/xylazine anesthesia and oropharyngeal aspiration improve lung delivery compared to isoflurane and intranasal dosing.

CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

Treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

A non-ligand surrogate agonist antibody that enhances canonical Wnt signaling and bone regeneration

This paper describes an antibody that enhances Wnt signaling and promotes bone regeneration without requiring exogenous Wnt ligands, showing efficacy in a mouse model of bone loss.

Organ-Specific Fuel Rewiring in Acute and Chronic Hypoxia Redistributes Glucose and Fatty Acid Metabolism

This study examines how systemic hypoxia alters fuel metabolism across organs, revealing distinct metabolic adaptations in acute versus chronic hypoxia.

Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

The paper identifies NOSEMPE in brown adipocytes as a cause of mitochondrial ETC imbalance and shows it drives nonmitochondrial thermogenesis and metabolic improvement via ATF4 activation.