Author

J.-I. Park

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

J. Zhang· 7 shared S. Jun· 7 shared G. Zou· 6 shared K.-P. Ko· 6 shared S. Zhang· 6 shared Y. Huang· 6 shared B. Kim· 5 shared K.-S. PARK· 4 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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7 shared papersCancer Biology

J. Zhang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

CRACD suppresses neuroendocrinal plasticity of lung adenocarcinoma

B. Kim, S. Zhang, Y. Huang, K.-P. Ko, G. Zou, J. Zhang, S. Jun, K.-B. Kim, Y.-S. Jung, K.-S. PARK, J.-I. Park

This study shows CRACD suppresses neuroendocrinal plasticity in lung adenocarcinoma by restricting cell de-differentiation and stemness-related pathways.

bioRxiv · Apr 19, 2023 · PreprintCancer Biology

CDH1 loss defines distinct diffuse-gastric cancer subtype with T cell exhaustion and EZH2 regulon activation

G. Zou, Y. Huang, S. Zhang, K.-P. Ko, B. J. Kim, J. Zhang, V. Venkatesan, M. P. Pizzi, S. Jun, N. Niu, H. Wang, S. Song, J. A. Ajani, J.-I. Park

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

bioRxiv · Mar 23, 2023Cancer Biology

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer

K.-P. Ko, S. Zhang, Y. Huang, B. Kim, G. Zou, S. Jun, J. Zhang, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Zhang, H. Nakagawa, J.-I. Park

This study defines ESCC subtypes based on tumor microenvironment transcriptional networks and predicts immunotherapy response using single-cell transcriptomics.

bioRxiv · Feb 15, 2023Cancer Biology

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

Y. Seo, S. Zhang, J. Jang, K.-P. Ko, K.-B. Kim, Y. Huang, D.-W. Kim, B. Kim, G. Zou, J. Zhang, S. Jun, W. Chu, N. A. Kirk, Y. E. Hwang, Y. H. Ban, , J.-I. Park

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

bioRxiv · Feb 15, 2023Cancer Biology

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

K.-P. Ko, Y. Huang, S. Zhang, G. Zou, B. Kim, J. Zhang, S. Jun, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Nakagawa, J.-I. Park

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

bioRxiv · Oct 13, 2022Cancer Biology

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

B. Kim, Y. Huang, K.-P. Ko, S. Zhang, G. Zou, J. Zhang, M. Kim, D. Little, L. V. Ellis, M. Paschini, S. Jun, K.-S. Park, J. Chen, C. Kim, J.-I. Park

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

bioRxiv · Oct 11, 2022Cell Biology

WNT5A-RHOA axis is a new vulnerability in small-cell lung cancer

K.-B. Kim, D.-W. Kim, Y. Kim, J. Tang, N. Kirk, Y. Gan, B. Fang, J.-I. Park, Y. Zheng, K.-S. Park

This study identifies the WNT5A-RHOA axis as a critical driver of small-cell lung cancer, offering new therapeutic targets and insights into WNT signaling heterogeneity.

bioRxiv · Apr 14, 2022 · PreprintCancer Biology

High-throughput imaging of Caenorhabditis elegans aging using collective activity monitoring

A. D. Fouad, M. A. Churgin, J. Hayden, J. Xu, J.-I. Park, A. Liu, C. Teng, H. Sun, M. Parrado, P. Bowlin, M. de la Torre, T. A. Crombie, C. Sedore, A. L. Coleman-Hulbert, E. Johnson, , C. Fang-Yen

The paper introduces WormCamp, a high-throughput system for aging research in C. elegans, showing it can estimate lifespan and healthspan through collective activity monitoring.

bioRxiv · Oct 18, 2021 · PreprintBioengineering

Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

H. N. Suh, M. J. Kim, S. H. Lee, S. Jun, J. Zhang, R. L. Johnson, J.-I. Park

This study identifies Tert+ acinar cells as critical for pancreatic regeneration, showing their activation by Yap/Taz and their role in tissue repair.

bioRxiv · Aug 30, 2021 · PreprintCell Biology