Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma
J. H. Choe, P. B. Watchmaker, M. S. Simic, R. D. Gilbert, A. W. Li, N. A. Krasnow, D. A. Carrera, W. Yu, K. M. Downey, A. Celli, J. Cho, J. D. Briones, R. Dannenfelser, L. Cardarelli, S. S. Sidhu, , W. A. Lim
This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.
bioRxiv · Jan 7, 2021 · PreprintImmunology