Author

K. M. Downey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. J. Alverson· 2 shared E. C. Ruck· 2 shared E. Pinseel· 2 shared H. Okada· 2 shared A. Celli· 1 shared A. Godhe· 1 shared A. Kremp· 1 shared A. L. Mende· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

A. J. Alverson

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Author profile →

4 papers

Recent·Most cited

Resolving marine-freshwater transitions by diatoms through a fog of gene tree discordance

W. R. Roberts, E. C. Ruck, K. M. Downey, E. Pinseel, A. J. Alverson

This study uses phylogenomic data to resolve freshwater transitions in diatoms, finding evidence of homoplasy over hemiplasy in adaptation to low salinity.

bioRxiv · Aug 12, 2022 · PreprintEvolutionary Biology

Genotype-specific transcriptional responses overshadow salinity effects in a marine diatom sampled along the Baltic Sea salinity cline

E. Pinseel, T. Nakov, K. Van den Berge, K. M. Downey, K. J. Judy, O. Kourtchenko, A. Kremp, E. C. Ruck, C. Sjoqvist, M. Topel, A. Godhe, A. J. Alverson

This study shows that genotype-specific transcriptional responses are more significant than salinity effects in a marine diatom adapting to low salinity in the Baltic Sea.

bioRxiv · Nov 4, 2021 · PreprintMicrobiology

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

P. Chuntova, Y. Hou, R. Naka, Y. Goretsky, T. Nejo, G. Kohanbash, T. Chen, A. L. Mende, M. Montoya, A. Yamamichi, K. M. Downey, D. Diebold, J. Skinner, H.-E. Liang, B. Schwer, H. Okada

This paper develops a novel transgenic mouse model expressing EGFRvIII-CAR on T-cells to study CAR T-cell therapy in syngeneic glioblastoma models.

bioRxiv · Jan 31, 2021Immunology

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

J. H. Choe, P. B. Watchmaker, M. S. Simic, R. D. Gilbert, A. W. Li, N. A. Krasnow, D. A. Carrera, W. Yu, K. M. Downey, A. Celli, J. Cho, J. D. Briones, R. Dannenfelser, L. Cardarelli, S. S. Sidhu, , W. A. Lim

This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.

bioRxiv · Jan 7, 2021 · PreprintImmunology