H. Okada

IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma

This study shows that delivering IRF8 via retroviral vector reprograms myeloid cells in glioblastoma, enhancing anti-tumor immunity and reducing immunosuppression.

A fatal case of peritonitis caused by Dysgonomonas capnocytophagoides harboring the novel metallo-beta-lactamase gene blaDYB-1

The paper reports a fatal peritonitis case caused by Dysgonomonas capnocytophagoides carrying a novel metallo-beta-lactamase gene and an ermFS gene associated with multidrug resistance.

Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

Bni5 tethers myosin-II to septins to enhance retrograde actin flow and the robustness of cytokinesis

This study identifies Bni5's role in tethering myosin-II to septins in budding yeast, enhancing retrograde actin flow and cytokinesis robustness.

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: differential and interactive effects on novelty-induced hyperlocomotion, blood cytokine levels and TRL4-related processes

This study compares the effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mouse behavior, cytokine levels, and TLR4 signaling, finding differential impacts on locomotion and cytokine responses.

Glioma-neuronal circuit remodeling induces regional immunosuppression

This study shows that glioma-induced neuronal circuit remodeling creates regional immunosuppression in glioblastomas by altering tumor-associated macrophages and T-cell infiltration.

Trichinella spiralis secretes stage-specific extracellular vesicles for modulating host microenvironment for parasitism.

This study identifies stage-specific extracellular vesicles from Trichinella spiralis that modulate host microenvironment through unique and shared biomolecules to support parasitism.

In vivo reprogramming of wound-resident cells generates skin with hair

This study reprograms wound-resident cells in adult mice to generate skin with hair follicles, demonstrating de novo appendage formation.

Sex-specific T cell exhaustion drives differential immune responses in glioblastoma

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice

This study shows that β-damascone, a rose compound, activates the NRF2 pathway in dendritic cells to reduce immune responses and alleviate contact hypersensitivity in mice.

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

This paper develops a novel transgenic mouse model expressing EGFRvIII-CAR on T-cells to study CAR T-cell therapy in syngeneic glioblastoma models.

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.

MinION™, a portable long-read sequencer, enables rapid vaginal microbiota analysis in a clinical setting

The paper demonstrates that MinION sequencing enables rapid, high-resolution analysis of vaginal microbiota in a clinical setting, identifying species-level profiles associated with health and disease.

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution

This study compares full-length and short-read 16S rRNA gene sequencing using MinION and conventional methods to assess species-level resolution in human gut microbiota.