Author

N. A. Lambert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Lu· 3 shared W. Jang· 3 shared A. Inoue· 1 shared A. Manglik· 1 shared D. Jullie· 1 shared G. Feinberg· 1 shared J. Li· 1 shared K. Senarath· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersPharmacology & Toxicology

S. Lu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Visualization of endogenous G proteins on endosomes and other organelles

W. Jang, K. Senarath, G. Feinberg, S. Lu, N. A. Lambert

The paper visualizes endogenous G proteins on endosomes and other organelles using gene editing and microscopy, showing their distribution and trafficking.

bioRxiv · Mar 5, 2024Pharmacology & Toxicology

Nucleotide-decoupled G proteins reveal the role of G protein conformation in receptor-G protein selectivity

W. Jang, S. Lu, N. A. Lambert

This study investigates GPCR-G protein selectivity by using nucleotide-decoupled G protein variants, finding that selectivity decreases when nucleotide release is not required for complex formation.

bioRxiv · May 25, 2022Pharmacology & Toxicology

Constitutive G protein coupling profiles of understudied orphan GPCRs

S. Lu, W. Jang, A. Inoue, N. A. Lambert

The paper uses BRET to determine G protein coupling profiles of 48 orphan GPCRs without ligands, identifying 48 receptor-G protein pairs, many previously unknown.

bioRxiv · Feb 16, 2021Pharmacology & Toxicology

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

M. Stoeber, D. Jullie, J. Li, S. Chakraborty, S. Majumdar, N. A. Lambert, A. Manglik, M. von Zastrow

The paper develops a cell-based assay to study agonist-selective recruitment of engineered protein probes and GRK2 by opioid receptors in living cells, showing differential recruitment by distinct opioid ligands.

bioRxiv · Dec 5, 2019Cell Biology