S. Majumdar

Physics-informed machine learning for automatic model reduction in chemical reaction networks

This paper introduces a physics-informed machine learning framework for automatic model reduction in chemical reaction networks, enhancing efficiency and accuracy in simulating complex systems like Aβ fibril aggregation.

Negative allosteric modulation of the μ-opioid receptor

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

Atypical Chemokine Receptor 1 (Ackr1)-deficient Mice Resist Lethal SARS-CoV-2 Challenge

This study shows that Ackr1-deficient mice have lower mortality from SARS-CoV-2 infection, suggesting ACKR1 may contribute to COVID-19 immunopathology and could be a drug target.

The structure of a hibernating ribosome in a Lyme disease pathogen

This study determines the structure of the hibernating ribosome in Borrelia burgdorferi using cryo-EM, revealing new structural features and insights into antibiotic binding.

The small mycobacterial ribosomal protein, bS22, modulates aminoglycoside accessibility to its 16S rRNA helix-44 binding site

This study shows that the mycobacterial ribosomal protein bS22 modulates aminoglycoside binding to the 16S rRNA helix-44 site, influencing antibiotic resistance.

Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small-molecule antibiotics

The paper identifies a new potential drug-binding site in alanine racemase by combining computational analysis and experimental validation, suggesting it for allosteric antibiotic development.

RNASeq as a tool to understand dysregulation of potential biomarkers in HNSC

The paper uses RNASeq to identify differentially expressed genes in oral cancer, analyzes their functional enrichment, and identifies hub genes as potential biomarkers for margin clearance.

Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer

This study shows that reduced HOXA10 expression in mice leads to endometrial hyperplasia and cancer progression with age.

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States

This paper introduces a new class of iboga alkaloids, oxa-iboga, which show therapeutic efficacy in opioid use disorder without cardiac risks, as demonstrated in rat models.

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

Actin filament alignment causes mechanical hysteresis in cross-linked networks

The paper investigates how actin filament alignment affects mechanical hysteresis in cross-linked networks by varying cross-linker concentration and properties.

Predicting COVID-19 Severity with a Specific Nucleocapsid Antibody plus Disease Risk Factor Score

This paper identifies an antibody epitope and a risk score to predict severe COVID-19 outcomes with high specificity.

Oligomerisation of THAP9 transposase: role of DNA and amino-terminal domains

This study investigates the oligomerisation of hTHAP9 and DmTNP, showing DNA and amino-terminal domains are involved, with Hcf-1 and other THAP proteins as potential interaction partners.

Reengineering the Specificity of the Highly Selective Clostridium botulinum Protease via Directed Evolution

This study uses directed evolution to reengineer the BoNT/A protease to target SNAP23, improving its cleavage specificity and catalytic efficiency for therapeutic applications.

Exploring the maturation of a monocytic cell line using self-organizing maps of single-cell Raman spectra

This study uses self-organizing maps of single-cell Raman spectra to analyze how PMA stimulation and adhesion factors affect THP-1 cell differentiation into macrophage-like cells.

SARS-CoV-2 Spike Glycoprotein and ACE2 interaction reveals modulation of viral entry in wild and domestic animals

This study evaluates the interaction between SARS-CoV-2 spike protein and ACE2 receptors across species to predict viral entry probabilities in different animals.

A 'one-two punch' therapy strategy to target chemoresistance in estrogen receptor positive breast cancer

This study identifies a sequential therapy strategy using HDAC inhibitors to reverse chemotherapy-induced resistance in ER+ breast cancer by targeting cancer stem cell-like traits.

Protein induced membrane phase transition facilitates leishmania infection

This study shows that the Leishmania Donovani protein KMP-11 induces membrane phase transition in macrophages, facilitating infection by altering membrane tension and lipid raft structure.

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

The paper develops a cell-based assay to study agonist-selective recruitment of engineered protein probes and GRK2 by opioid receptors in living cells, showing differential recruitment by distinct opioid ligands.

Vortex fluidics-mediated DNA rescue from formalin-fixed museum specimens

This paper develops a method using vortex fluidics to rescue DNA from formalin-fixed specimens, achieving PCR-amplifiable DNA recovery from American lobster tissue.

Absence of receptor guanylyl cyclase C enhances ileal damage and reduces cytokine and antimicrobial peptide production during oral Salmonella Typhimurium infection