Bioactive Natural Product Discovery via Deuterium Adduct Bioactivity Screening
N. A. Zill, Y. Du, S. Marinkovich, D. Gu, J. A. Seidel, W. Zhang
This paper introduces DABS, a new workflow for natural product discovery that combines isotope labeling with whole cell binding assays, leading to the identification of zillamycin with anti-cancer and anti-microbial activities.
bioRxiv · Mar 16, 2023 · PreprintMicrobiology