MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages
R. Dhanasekaran, A. S. Hansen, J. Park, I. Lai, N. Adeniji, S. Kuruvilla, A. Suresh, V. Swamy, D. W. Felsher
This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.
bioRxiv · May 13, 2022 · PreprintCancer Biology