Author

A. S. Hansen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Research Focus:chromatin & epigenetic regulation· 6 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2

Frequent Co-Authors

C. Cattoglio· 5 shared R. Tjian· 5 shared X. Darzacq· 5 shared I. Pustova· 3 shared A. Jha· 2 shared G. M. Dailey· 2 shared H. B. Brandao· 2 shared T.-H. S. Hsieh· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBiophysics

C. Cattoglio

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

A. S. Hansen, L. S. Jensen, K. G. Ryttersgaard, C. Krapp, J. Just, K. R. Gammelgaard, K. L. Jonsson, M. Johannsen, A. Etzerodt, B. W. Deleuran, M. R. Jakobsen

This study shows that T-cell derived extracellular vesicles enhance macrophage STING activation, improving cancer immunotherapy by reprogramming macrophages to a pro-inflammatory state.

bioRxiv · Jan 9, 2023Immunology

Determination of insulin secretion from stem cell-derived islets with liquid chromatography-tandem mass spectrometry

C. Olsen, C. Wang, S. Abadour, E. Lundanes, A. S. Hansen, F. S. Skottvoll, H. Scholz, S. R. Wilson

The paper develops a sensitive and selective RPLC-MS/MS method to quantify insulin secretion from islet organoids, overcoming carry-over and sensitivity issues with low-volume samples.

Journal of Chromatography B · Jan 1, 2023Peer-reviewedBioengineering

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages

R. Dhanasekaran, A. S. Hansen, J. Park, I. Lai, N. Adeniji, S. Kuruvilla, A. Suresh, V. Swamy, D. W. Felsher

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

bioRxiv · May 13, 2022 · PreprintCancer Biology

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

J. Mahadevan, A. Jha, J. Rudolph, S. Bowerman, D. Narducci, A. S. Hansen, K. Luger

This study uses live-cell single-molecule imaging to show that most PARP1/2 diffuse freely, with a small fraction transiently binding DNA after damage, suggesting new strategies for PARP inhibitors.

bioRxiv · Mar 12, 2022Biophysics

Dynamics of CTCF and cohesin mediated chromatin looping revealed by live-cell imaging

M. Gabriele, H. B. Brandao, S. Grosse-Holz, A. Jha, G. M. Dailey, C. Cattoglio, T.-H. S. Hsieh, L. Mirny, C. Zechner, A. S. Hansen

This study uses live-cell imaging to show that chromatin loops at the Fbn2 TAD are rare and dynamic, challenging the notion of stable TADs.

bioRxiv · Dec 12, 2021Biophysics

DNA double-strand break end synapsis by DNA loop extrusion

J. H. Yang, H. B. Brandao, A. S. Hansen

This study shows that DNA loop extrusion, with targeted loading and stabilization, enables efficient DSB end synapsis, challenging the assumption of passive diffusion.

bioRxiv · Oct 20, 2021Biophysics

Determining cellular CTCF and cohesin abundances to constrain 3D genome models

C. Cattoglio, I. Pustova, N. Walther, J. J. Ho, M. Hantsche-Grininger, C. J. Inouye, M. J. Hossain, G. M. Dailey, J. Ellenberg, X. Darzacq, R. Tjian, A. S. Hansen

The paper quantifies CTCF and cohesin levels in mammalian cells to improve 3D genome models and provides a method for measuring Halo-tagged proteins.

bioRxiv · Feb 24, 2019Biophysics

An RNA-binding region regulates CTCF clustering and chromatin looping

A. S. Hansen, T.-H. S. Hsieh, C. Cattoglio, I. Pustova, X. Darzacq, R. Tjian

The paper shows that an RNA-binding region in CTCF mediates chromatin looping and clustering, revealing two classes of CTCF loops: RBR-dependent and RBR-independent.

bioRxiv · Dec 16, 2018Biophysics

Guided nuclear exploration increases CTCF target search efficiency

A. S. Hansen, A. Amitai, C. Cattoglio, R. Tjian, X. Darzacq

This study shows that CTCF uses RNA-binding region-mediated trapping to increase its target search efficiency in the nucleus by ~2.5 fold.

bioRxiv · Dec 13, 2018Biophysics

Spot-On: robust model-based analysis of single-particle tracking experiments

A. S. Hansen, M. Woringer, J. B. Grimm, L. D. Lavis, R. Tjian, X. Darzacq

Spot-On provides a bias-corrected analysis tool for single-particle tracking experiments, outperforming existing methods and demonstrating robust inference of diffusion constants and subpopulations.

bioRxiv · Oct 26, 2017Biophysics

CTCF and Cohesin Regulate Chromatin Loop Stability with Distinct Dynamics

A. S. Hansen, I. Pustova, C. Cattoglio, R. Tjian, X. Darzacq

This study shows CTCF and cohesin form a dynamic complex with distinct binding dynamics, suggesting chromatin loops constantly break and reform.

bioRxiv · Dec 13, 2016Biophysics