Author

S. Kuruvilla

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. S. Hansen· 1 shared A. Suresh· 1 shared D. W. Felsher· 1 shared I. Lai· 1 shared J. Park· 1 shared N. Adeniji· 1 shared R. Dhanasekaran· 1 shared V. Swamy· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

A. S. Hansen

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1 paper

Recent·Most cited

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages

R. Dhanasekaran, A. S. Hansen, J. Park, I. Lai, N. Adeniji, S. Kuruvilla, A. Suresh, V. Swamy, D. W. Felsher

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

bioRxiv · May 13, 2022 · PreprintCancer Biology