Author

R. Dhanasekaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

A. Deutzmann· 1 shared A. Mosley· 1 shared A. S. Hansen· 1 shared A. Suresh· 1 shared C. Horton· 1 shared D. Felsher· 1 shared D. Liefwalker· 1 shared D. W. Felsher· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Deutzmann

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Author profile →

2 papers

Recent·Most cited

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages

R. Dhanasekaran, A. S. Hansen, J. Park, I. Lai, N. Adeniji, S. Kuruvilla, A. Suresh, V. Swamy, D. W. Felsher

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

bioRxiv · May 13, 2022 · PreprintCancer Biology

MYC Functions as a Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

S. Swaminathan, L. Heftdal, D. Liefwalker, R. Dhanasekaran, A. Deutzmann, C. Horton, A. Mosley, M. Libersbach, H. Maecker, D. Felsher

This study shows that MYC in lymphomas inhibits NK cell maturation by suppressing STAT1/2 and IFN secretion, and restoring NK cells improves survival in lymphoma models.

bioRxiv · Dec 28, 2018Cancer Biology