In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding
N. Bate, C. G. Savva, P. C. Moody, E. A. Brown, J. K. Ball, J. W. Schwabe, J. Sale, N. Brindle
The paper uses in vitro evolution to identify CoV-2 mutations that enhance ACE2 binding and cross-species transmission, finding mutations like Q498H and Q498R/N501Y that are emerging in variants like Omicron.
bioRxiv · Dec 23, 2021Biochemistry