Author

J. W. Schwabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. Fairall· 3 shared C. Dominguez· 2 shared A. Ferrari· 1 shared A. H. Bedard· 1 shared A. Hasan· 1 shared A. J. Hudson· 1 shared A. Nguyen· 1 shared B. Romartinez- Alonso· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

L. Fairall

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

A. Ferrari, E. Whang, X. Xiao, J. P. Kennelly, B. Romartinez- Alonso, J. J. Mack, T. Weston, K. Chen, Y. Kim, M. Tol, L. Bideyan, A. Nguyen, Y. Gao, L. Cui, A. H. Bedard, , P. Tontonoz

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

bioRxiv · Jul 7, 2023 · PreprintPhysiology

Structural insights into the complex of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator

M. Tariq, T. Ikeya, N. Togashi, L. Fairall, S. Kamei, S. Mayooramurugan, L. R. Abbott, A. Hasan, C. Bueno-Alejo, S. Sukegawa, B. Romartinez-Alonso, M. A. Muro Campillo, A. J. Hudson, Y. Ito, J. W. Schwabe, , K. Tanaka

This study investigates the structural interaction between oncogenic KRas4BG12V and Rgl2RA, revealing a unique tetrameric complex formation that explains its hyperactivation of the RalA/B pathway.

bioRxiv · Oct 10, 2022Biochemistry

An unexpected histone chaperone function for the MIER1 histone deacetylase complex

S. Wang, L. Fairall, K. Pham, T. J. Ragan, D. Vashi, M. O. Collins, C. Dominguez, J. W. Schwabe

The paper identifies an unexpected histone chaperone function for the MIER1 histone deacetylase complex, showing its ability to bind histone dimers and octamers and associate with nucleosomes.

bioRxiv · Jul 22, 2022 · PreprintBiochemistry

In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding

N. Bate, C. G. Savva, P. C. Moody, E. A. Brown, J. K. Ball, J. W. Schwabe, J. Sale, N. Brindle

The paper uses in vitro evolution to identify CoV-2 mutations that enhance ACE2 binding and cross-species transmission, finding mutations like Q498H and Q498R/N501Y that are emerging in variants like Omicron.

bioRxiv · Dec 23, 2021Biochemistry