Author

E. A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:rat· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Organism:human· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. M. Mitzey· 2 shared A. M. Weiler· 2 shared A. Mejia· 2 shared A. Possell· 2 shared A. S. Jaeger· 2 shared C. M. Crooks· 2 shared E. L. Mohr· 2 shared E. Peterson· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. M. Mitzey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

finsyncR, an R package to synchronize 27 years of fish and invertebrate data across the United States

M. B. Mahon, D. K. Jones, R. A. Hill, T. N. Brown, E. A. Brown, S. Kunz, S. L. Rumschlag

finsyncR simplifies access to and integration of 27 years of fish and macroinvertebrate data from US streams and rivers, providing cleaned datasets and tools to address common data challenges.

bioRxiv · Feb 22, 2024 · PreprintEcology

In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding

N. Bate, C. G. Savva, P. C. Moody, E. A. Brown, J. K. Ball, J. W. Schwabe, J. Sale, N. Brindle

The paper uses in vitro evolution to identify CoV-2 mutations that enhance ACE2 binding and cross-species transmission, finding mutations like Q498H and Q498R/N501Y that are emerging in variants like Omicron.

bioRxiv · Dec 23, 2021Biochemistry

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

C. M. Crooks, A. M. Weiler, S. L. Rybarczyk, M. I. Bliss, A. S. Jaeger, M. E. Murphy, H. A. Simmons, A. Mejia, M. K. Fritsch, J. M. Hayes, J. C. Eickhoff, A. M. Mitzey, E. Razo, K. M. Braun, E. A. Brown, , M. T. Aliota

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

bioRxiv · Jan 25, 2021 · PreprintMicrobiology

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

C. M. Crooks, A. M. Weiler, S. L. Rybarczyk, M. I. Bliss, A. S. Jaeger, M. E. Murphy, H. A. Simmons, A. Mejia, M. K. Fritsch, J. M. Hayes, J. C. Eickhoff, A. M. Mitzey, E. Razo, K. Braun, E. A. Brown, , T. C. Friedrich

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.

bioRxiv · Nov 30, 2020Microbiology

Reporter assays for Ebola virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111

A. E. Lin, W. E. Diehl, Y. Cai, C. L. Finch, C. Akusobi, R. N. Kirchdoerfer, L. Bollinger, S. F. Schaffner, E. A. Brown, E. O. Saphire, K. G. Andersen, J. H. Kuhn, J. Luban, P. C. Sabeti

The paper develops reporter assays to study Ebola virus nucleoprotein (NP) function and finds that amino acid position 111 affects oligomerization, virion budding, and transcription/replication.

bioRxiv · Dec 10, 2019Microbiology