N. Casadei

Comparative multi-OMICS single-cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action

This study compares the mechanisms of action of five COVID-19 vaccines using multi-omics single-cell data, revealing distinct immune responses and cell-type-specific effects.

Immune dynamics at single cell protein level after delta/omicron infection in COVID-19 vaccinated convalescent individuals

This study examines immune dynamics at the protein level in vaccinated individuals infected with delta or omicron variants, finding reduced NK cells and increased T and B cells, and that booster doses reduce infection severity.

Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women

This study uses single-cell RNA sequencing to show that SARS-CoV-2 infection reduces cytotoxic function in natural killer and CD8+ T cells in recovered pregnant women.

Genome-wide CRISPR and small-molecule screens uncover targetable dependencies in ATRT

This study identifies targetable genetic dependencies in ATRT using CRISPR and small-molecule screens, revealing CDK4/6 inhibitors as potent therapeutic options.

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

This study examines how SARS-CoV-2 infection affects CD8+ T cell cytotoxicity and immune cell metabolism in COVID-19 patients.

DJ-1 (Park7) affects the gut microbiome, metabolites, and development of Innate Lymphoid Cells (ILCs)

This study shows that DJ-1 deficiency in mice alters gut microbiome composition, increases inflammatory markers, and reduces innate lymphoid cells, potentially contributing to Parkinson's disease pathogenesis.