Author

T. W. Mak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. C. Wang· 1 shared A. Dhariwal· 1 shared A. J. Elia· 1 shared A. Janzer· 1 shared A. Sutter· 1 shared B. Huang· 1 shared B. Pulendran· 1 shared B. Wu· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. C. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification

C. Zhang, B. Wu, Y. F. Wu, C. di Ciano-Oliveira, I. Soria-Bretones, N.-A. Pham, A. J. Elia, R. Chari, W. L. Lam, M. R. Bray, T. W. Mak, M.-S. Tsao, D. W. Cescon, K. L. Thu

This study identifies KIFC1 as a therapeutic vulnerability in lung cancers with centrosome amplification by showing its role in mitigating mitotic stress.

bioRxiv · Jan 9, 2024Cancer Biology

Inhibition of CHK2 dependent DNA damage response suppresses Zika virus infection through a STING dependent mechanism

H. Ma, C. Li, Y. Wang, E. V. Valore, M. Trisal, H. Sai-yin Hui, P. Hakimpour, J. R. Bowen, T. W. Mak, M. S. Suthar, B. Pulendran

This study shows that inhibiting CHK2 reduces ZIKV production and rescues developmental defects by enhancing STING-dependent antiviral responses.

bioRxiv · Oct 3, 2022 · PreprintImmunology

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

D. D. Shi, M. R. Savani, M. M. Levitt, A. C. Wang, J. E. Endress, C. E. Bird, J. Buehler, S. A. Stopka, M. S. Regan, Y.-F. Lin, W. Gao, J. Khanal, M. Xu, B. Huang, R. B. Jennings, , McBray

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

bioRxiv · Nov 30, 2021Cancer Biology

DJ-1 (Park7) affects the gut microbiome, metabolites, and development of Innate Lymphoid Cells (ILCs)

Y. Singh, C. Trautwein, A. Dhariwal, M. S. Salker, M. Alauddin, L. Zizmare, L. Pelzl, M. Feger, J. Matthes, N. Casadei, M. Föller, V. Pachauri, D. S. Park, T. W. Mak, J. S. Frick, , O. Riess

This study shows that DJ-1 deficiency in mice alters gut microbiome composition, increases inflammatory markers, and reduces innate lymphoid cells, potentially contributing to Parkinson's disease pathogenesis.

bioRxiv · Sep 19, 2019Immunology