N. Coll-Bonfill

Progerin triggers a phenotypic switch in vascular smooth muscle cells that causes replication stress and an aging-associated secretory signature

This study shows that progerin induces a phenotypic switch in vascular smooth muscle cells, causing replication stress and an aging-associated secretory signature, contributing to vascular stiffness in progeria.

A-type lamins are critical for the recruitment of RPA and RAD51 to stalled replication forks to maintain fork stability

This study shows A-type lamins are essential for recruiting RPA and RAD51 to stalled replication forks, preventing replication fork instability during replication stress.