Author

R. P. Mecham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1

Frequent Co-Authors

C.-J. Lin· 2 shared B. Corliss· 1 shared B. E. Isakson· 1 shared B. M. Brengle· 1 shared C. A. Ruddiman· 1 shared C. M. Halabi· 1 shared J. E. Wagenseil· 1 shared K. Jones· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

C.-J. Lin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Polarized localization of phosphatidylserine in endothelium regulates Kir2.1

C. A. Ruddiman, R. Peckham, M. A. Luse, Y. L. A. Chen, M. Kuppusamy, B. Corliss, P. J. Hall, C.-J. Lin, S. M. Peirce, S. K. Sonkusare, R. P. Mecham, J. E. Wagenseil, B. E. Isakson

The paper shows phosphatidylserine (PS) localizes to myoendothelial junctions (MEJs) in endothelium, inhibiting PIP2-mediated Kir2.1 activation to regulate vascular diameter.

bioRxiv · Aug 1, 2022Physiology

Mutation in the matricellular gene fibulin-4 leads to endothelial dysfunction in resistance arteries

M. Lin, K. Jones, B. M. Brengle, R. P. Mecham, C. M. Halabi

This study shows that fibulin-4 mutations cause endothelial dysfunction in resistance arteries due to increased shear stress and oxidative environment.

bioRxiv · May 20, 2022 · PreprintPhysiology

Progerin triggers a phenotypic switch in vascular smooth muscle cells that causes replication stress and an aging-associated secretory signature

N. Coll-Bonfill, U. Mahajan, C.-J. Lin, R. P. Mecham, S. Gonzalo

This study shows that progerin induces a phenotypic switch in vascular smooth muscle cells, causing replication stress and an aging-associated secretory signature, contributing to vascular stiffness in progeria.

bioRxiv · Feb 5, 2022 · PreprintCell Biology