N. D. Hatch

Identification of the alternative sigma factor regulons of Chlamydia trachomatis using multiplexed CRISPR interference

This study identifies the regulons of two alternative sigma factors in Chlamydia trachomatis by using CRISPR interference and RNA sequencing, showing their essential roles in late-stage development.

Regulation of an iron-dependent repressor by tryptophan availability attenuates transcription of the tryptophan salvage genes in Chlamydia trachomatis

The paper shows that YtgR represses trpBA expression in Chlamydia trachomatis by sensing both iron and tryptophan levels, using a rare triple-tryptophan motif to regulate transcription termination.

Inhibition of tRNA Synthetases Induces Persistence in Chlamydia

This study shows that tRNA synthetase inhibitors induce chlamydial persistence independently of IFN-gamma by mimicking amino acid starvation.