Author

N. D. Perkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

J. E. Hunter· 3 shared C. E. Eyers· 2 shared L.-I. Su· 2 shared P. J. Brownridge· 2 shared A. Campbell· 1 shared A. E. Campbell· 1 shared A. I. Yemm· 1 shared A. R. Jones· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

J. E. Hunter

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Disruption of HIF1A translational control attenuates the HIF-dependent hypoxic response and solid tumour formation in vivo

J. E. Hunter, O. McHugh, G. B. Ecclestone, F. Child, H. Mearns, G. Robson, M. Dadzie, S. Rocha, N. D. Perkins, N. S. Kenneth

This study shows that disrupting HIF1A translational control reduces hypoxic response and solid tumour formation in mice.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

J. E. Hunter, A. E. Campbell, N. L. Hannaway, S. Kerridge, S. Luli, J. A. Butterworth, H. Sellier, R. Mukherjee, H. D. Thomas, P. J. Brownridge, J. Coxhead, L. Taylor, P. Leary, M. S. R. Hasoon, I. Collins, , N. D. Perkins

The paper identifies a c-Rel and USP1 dependent pathway that regulates CHK1 inhibitor resistance in lymphoma cells.

bioRxiv · May 26, 2021Cancer Biology

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage

A. Campbell, C. Ferraz Franco, L.-I. Su, S. Perkins, A. R. Jones, P. J. Brownridge, N. D. Perkins, C. E. Eyers

This study examines how different DNA damage agents modulate the phosphorylation of RelA and its interactome over time, revealing distinct signaling pathways and cellular outcomes.

bioRxiv · Aug 11, 2020Biochemistry

Parallel siRNA screens to identify kinase and phosphatase modulators of NF-κB activity following DNA damage

A. Sfikas, P. Banks, L.-I. Su, G. Schlossmacher, N. D. Perkins, A. I. Yemm

The paper identifies kinase and phosphatase modulators of NF-κB activity after DNA damage using RNAi screens but highlights inconsistencies between two independent screens.

bioRxiv · Dec 5, 2019 · PreprintCell Biology

A pseudo-meiotic centrosomal function of TEX12 in cancer

S. Sandhu, L. J. Salmon, J. E. Hunter, C. L. Wilson, N. D. Perkins, N. Hunter, O. R. Davies, U. L. McClurg

The paper identifies TEX12 as a meiosis-specific gene aberrantly expressed in cancer, showing its role in centrosome dysfunction and oncogenesis.

bioRxiv · Jan 8, 2019 · PreprintCell Biology