Author

P. J. Brownridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. E. Eyers· 5 shared A. R. Jones· 2 shared D. P. Byrne· 2 shared L. A. Daly· 2 shared N. D. Perkins· 2 shared P. A. Eyers· 2 shared S. Perkins· 2 shared A. Campbell· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersBiochemistry

C. E. Eyers

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Author profile →

6 papers

Recent·Most cited

A bespoke analytical workflow for the confident identification of sulfopeptides and their discrimination from phosphopeptides

L. A. Daly, D. P. Byrne, S. Perkins, P. J. Brownridge, E. McDonnell, A. R. Jones, P. A. Eyers, C. E. Eyers

This study develops a mass spectrometry workflow to identify sulfotyrosine peptides and distinguish them from phosphotyrosine peptides, identifying 21 new sulfotyrosine-containing proteins.

bioRxiv · Jul 15, 2023 · PreprintBiochemistry

Exploring the conformational landscape and stability of Aurora A using ion-mobility mass spectrometry and molecular modelling

L. J. Tomlinson, M. Bachelor, D. P. Byrne, J. Sarsby, P. J. Brownridge, R. Bayliss, P. A. Eyers, C. E. Eyers

This study uses ion-mobility mass spectrometry and molecular modeling to analyze conformational changes in Aurora A kinase induced by TPX2 activation and inhibitor binding.

Journal of the American Society for Mass Spectrometry · Jan 31, 2022Peer-reviewedBiochemistry

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

J. E. Hunter, A. E. Campbell, N. L. Hannaway, S. Kerridge, S. Luli, J. A. Butterworth, H. Sellier, R. Mukherjee, H. D. Thomas, P. J. Brownridge, J. Coxhead, L. Taylor, P. Leary, M. S. R. Hasoon, I. Collins, , N. D. Perkins

The paper identifies a c-Rel and USP1 dependent pathway that regulates CHK1 inhibitor resistance in lymphoma cells.

bioRxiv · May 26, 2021Cancer Biology

Oxygen-dependent changes in HIF binding partners and post-translational modifications regulate stability and transcriptional activity

L. A. Daly, P. J. Brownridge, V. See, C. E. Eyers

The paper investigates how oxygen levels affect HIF-1 and HIF-2 stability and activity through post-translational modifications and interactions, identifying novel oxygen-dependent PTMs and regulatory roles.

bioRxiv · Nov 12, 2020Biochemistry

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage

A. Campbell, C. Ferraz Franco, L.-I. Su, S. Perkins, A. R. Jones, P. J. Brownridge, N. D. Perkins, C. E. Eyers

This study examines how different DNA damage agents modulate the phosphorylation of RelA and its interactome over time, revealing distinct signaling pathways and cellular outcomes.

bioRxiv · Aug 11, 2020Biochemistry

The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis

Q. M. Nunes, D. Su, P. J. Brownridge, D. M. Simpson, C. Sun, y. li, P. T. P. Bui, X. Zhang, W. Huang, D. J. Rigden, R. J. Beynon, R. Sutton, D. G. Fernig

This study identifies extracellular heparin-binding proteins (HBPs) in normal and acute pancreatitis mouse pancreas and plasma, revealing their roles in homeostasis and inflammation.

PLOS ONE · Jun 18, 2019Peer-reviewedBiochemistry