Author

N. S. Kenneth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

G. B. Ecclestone· 2 shared A. Acharjee· 1 shared A. Collins· 1 shared A. Sanz· 1 shared B. Carroll· 1 shared C. Bascom· 1 shared C. L. Wilson· 1 shared D. A. Mann· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

G. B. Ecclestone

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.

A. Collins, R. Scott, C. L. Wilson, G. Abbate, G. B. Ecclestone, D. Biddles, F. Oakley, J. Mann, D. A. Mann, N. S. Kenneth

This study shows that UCHL1 regulates HIF1 activity in liver fibrosis by cleaving ubiquitin chains, increasing HIF1 levels, and promoting fibrosis.

bioRxiv · Jan 8, 2023 · PreprintCell Biology

Disruption of HIF1A translational control attenuates the HIF-dependent hypoxic response and solid tumour formation in vivo

J. E. Hunter, O. McHugh, G. B. Ecclestone, F. Child, H. Mearns, G. Robson, M. Dadzie, S. Rocha, N. D. Perkins, N. S. Kenneth

This study shows that disrupting HIF1A translational control reduces hypoxic response and solid tumour formation in mice.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

L. Sedlackova, E. G. Otten, F. Scialo, D. Shapira, T. Kataura, B. Carroll, E. Seranova, Y. Rabanal Ruiz, G. Kelly, R. Stefanatos, G. Nelson, F. Urselli, A. Acharjee, N. S. Kenneth, S. A. Trushin, , V. I. Korolchuk

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

bioRxiv · Jan 31, 2020 · PreprintCell Biology