Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis
Y. Watanabe, K. Kinoshita, N. Dumrongkulchart, T. Sasaki, M. Shimizu, Y. Yamauchi, R. Sato
This study shows that restoring CYP7B1 expression reduces NASH progression in mice, linking its downregulation to lipid and oxidative stress in the early stages of the disease.
bioRxiv · May 10, 2023 · PreprintBiochemistry