K. Kinoshita

Multi-omics profiling reveals phenotypic and functional heterogeneity of neutrophils in COVID-19

This study identifies eight neutrophil subtypes in COVID-19 using multi-omics data and finds that subtype C4 is associated with severe disease and may serve as a diagnostic biomarker.

Elevator motion of chloride ion transporter SLC26A9 induced by STAS domain

This study uses molecular dynamics simulations to show that removing the C-terminus of SLC26A9 enhances STAS domain motion, which gates the transmembrane domain to promote chloride ion transport.

Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis

This study shows that restoring CYP7B1 expression reduces NASH progression in mice, linking its downregulation to lipid and oxidative stress in the early stages of the disease.

Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

This study shows that the N-terminal tail of CAP-H regulates condensin I loading in a cell cycle-specific manner through phosphorylation and deletion effects in Xenopus extracts.

Elasticity control of entangled chromosomes: crosstalk between condensin complexes and nucleosomes

The paper constructs a theoretical model to explain the formation of a unique bean-shaped structure formed by mutant condensin complexes and nucleosomes in Xenopus egg extracts.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays

This study investigates the role of condensin II subunits in chromosome assembly using Xenopus egg extracts, revealing distinct functional roles of CAP-D3 and CAP-G2.

Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers

The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.

Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion

This study shows IRSp53 promotes tumor cell proliferation through microvesicle secretion, as evidenced by reduced secretion and phosphorylation in knockout cells and increased survival in IRSp53-deficient mice.

Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex

This study reports the crystal structure of the human condensin I subcomplex hCAP-G and hCAP-H, revealing their interaction and DNA binding capabilities essential for mitotic chromosome assembly.

Molecular mechanism of depolarization-dependent inactivation in W366F mutant of Kv1.2

The paper investigates the molecular mechanism of C-type inactivation in a Kv1.2 mutant using molecular dynamics simulations and 3D-RISM analysis.