R. Sato

ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice

This study shows ABCA1 deficiency leads to tissue-specific SREBP2 pathway dysregulation in mice, depending on nutritional status, contributing to cholesterol deposition and atherosclerosis.

Engineered Active Zymogen of Microbial Transglutaminase

This paper designs an engineered active zymogen of microbial transglutaminase (EzMTG) that exhibits cross-linking activity without requiring proteolysis, and identifies mutations that balance binding affinity and catalytic activity.

Fruitless mating with the exes: the irreversible parthenogenesis in a stick insect

This study examines sexual reproduction in the Japanese stick insect Ramulus mikado, finding that rare males lack sperm and offspring show no paternal alleles, supporting irreversible asexual reproduction.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis

This study shows that restoring CYP7B1 expression reduces NASH progression in mice, linking its downregulation to lipid and oxidative stress in the early stages of the disease.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

Hydroxylation site-specific and production-dependent roles of endogenous oxysterols in cellular cholesterol homeostasis

This study investigates how endogenously synthesized oxysterols regulate cholesterol homeostasis by affecting SREBP-2 and LXR, showing site-specific and production-dependent effects.

Skeletal muscle releases extracellular vesicles with distinct protein and miRNA signatures that accumulate and function within the muscle microenvironment

This study identifies markers for skeletal muscle-derived extracellular vesicles (SkM-EVs) and shows they mainly function within the muscle microenvironment rather than contributing significantly to plasma EVs.

Recombinant production of active microbial transglutaminase in E. coli using self-cleavable zymogen with mutated propeptide

This paper describes the production of active microbial transglutaminase in E. coli using a modified zymogen with mutations in the propeptide to achieve pure, active enzyme.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.

DLDG1, the Arabidopsis Homolog of the Cyanobacterial H+-Extrusion Protein, Regulates Non-Photochemical Quenching in Chloroplasts

This study identifies DLDG1 as a protein regulating non-photochemical quenching in Arabidopsis chloroplasts by interacting with Ycf10 to control H+ homeostasis.

The two-step chemosensory system underlying the oligophagy of silkworm larvae

This study identifies a two-step chemosensory system in silkworm larvae that integrates plant chemical cues to determine host acceptance.

A mannitol/sorbitol receptor stimulates dietary intake in Tribolium castaneum

This study identifies TcGr20 as a mannitol/sorbitol receptor in Tribolium castaneum that facilitates dietary intake through chemosensory perception.

Towards Water-Free Biobanks: Long-Term Dry-Preservation At Room Temperature Of Desiccation-Sensitive Enzyme Luciferase In Air-Dried Insect Cells

This study demonstrates that desiccation-tolerant insect cells can preserve exogenous luciferase activity for over 372 days at room temperature through a trehalose preincubation process.