Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
W. Wei, M. J. Geer, X. Guo…·B. G. Neel
This study identifies genes conferring resistance to SHP2 inhibitors through CRISPR screens and shows their roles in reactivating ERK signaling in cancer cells.
A. Mendez-Mancilla, H.-H. Wessels, M. Legut…·N. E. Sanjana
The paper identifies chemically modified crRNAs that enhance CRISPR-Cas13 knockdown efficiency and half-life in human cells.
M. Legut, Z. Daniloski, X. Xue…·N. E. Sanjana
The paper compares PAM-flexible Cas9 variants (xCas9 and Cas9-NG) and wild-type Cas9 across gene knock-out, activation, and suppression using a high-throughput screen, finding that PAM flexibility reduces targeting efficiency and that Cas9-NG outperforms xCas9.
R. J. Kishton, S. J. Patel, S. K. Vodnala…·N. P. Restifo
This study identifies genes that tumor cells use to resist T cell killing and shows that inhibiting BIRC2, ITGAV, or DNPEP enhances T cell-mediated tumor destruction.