Author

N. E. Wheeler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:bacteria (other)· 2 Research Focus:variant effect prediction· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. L. Hicks· 2 shared K. C. Ma· 2 shared L. Sanchez-Buso· 2 shared T. D. Mortimer· 2 shared Y. H. Grad· 2 shared A. Cloutier· 1 shared A. J. Baker· 1 shared D. A. Williamson· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. L. Hicks

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

K. C. Ma, T. D. Mortimer, A. L. Hicks, N. E. Wheeler, L. Sanchez-Buso, D. Golparian, G. Taiaroa, D. H. Rubin, Y. Wang, D. A. Williamson, M. Unemo, S. R. Harris, Y. H. Grad

This study identifies loss-of-function mutations in efflux pumps as a mechanism for increased antibiotic susceptibility in Neisseria gonorrhoeae cervical isolates.

Nature Communications · Aug 17, 2020Peer-reviewedMicrobiology

Increased power from bacterial genome-wide association conditional on known effects identifies Neisseria gonorrhoeae macrolide resistance mutations in the 50S ribosomal protein L4

K. C. Ma, T. D. Mortimer, M. A. Duckett, A. L. Hicks, N. E. Wheeler, L. Sanchez-Buso, Y. H. Grad

This study uses conditional GWAS to identify a new azithromycin resistance mutation in Neisseria gonorrhoeae, demonstrating its prevalence and geographic spread.

bioRxiv · Mar 24, 2020Microbiology

Improved inference and prediction of bacterial genotype-phenotype associations using pangenome-spanning regressions

J. A. Lees, T. T. Mai, M. Galardini, N. E. Wheeler, J. Corander

This paper introduces a joint modeling framework for bacterial GWAS that improves statistical power and phenotype prediction while maintaining interpretability and computational efficiency.

bioRxiv · Nov 23, 2019 · PreprintMicrobiology

Convergent regulatory evolution and the origin of flightlessness in palaeognathous birds

T. B. Sackton, P. Grayson, A. Cloutier, Z. Hu, J. S. Liu, N. E. Wheeler, P. P. Gardner, J. A. Clarke, A. J. Baker, M. Clamp, S. V. Edwards

This study shows that convergent flightlessness in palaeognathous birds is associated with regulatory changes rather than protein-coding gene evolution.

bioRxiv · Feb 8, 2018Evolutionary Biology