T. D. Mortimer

Neisseria gonorrhoeae diagnostic escape from a gyrA-based test for ciprofloxacin susceptibility can lead to increased zoliflodacin resistance

The paper shows that Neisseria gonorrhoeae can escape ciprofloxacin susceptibility testing by reverting gyrA mutations, leading to zoliflodacin resistance.

Loci for prediction of penicillin and tetracycline susceptibility in Neisseria gonorrhoeae: a genome wide association study

This study identifies two chromosomal loci, penA_01 and rpsJ codon 57, along with plasmid loci blaTEM and tetM, that predict penicillin and tetracycline susceptibility in Neisseria gonorrhoeae with high specificity.

Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis

This study uses experimental evolution of Mycobacterium tuberculosis to identify genetic loci associated with biofilm formation and shows that regulatory mutations rapidly adapt under selective pressure.

Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae

This study traces the emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae by analyzing genome sequences from multiple countries and time periods, revealing recombination events and antibiotic-driven mutations.

Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

This study identifies loss-of-function mutations in efflux pumps as a mechanism for increased antibiotic susceptibility in Neisseria gonorrhoeae cervical isolates.

Efflux pump antibiotic binding site mutations are associated with azithromycin nonsusceptibility in clinical Neisseria gonorrhoeae isolates

The study confirms that specific MtrD efflux pump mutations in Neisseria gonorrhoeae are linked to increased azithromycin nonsusceptibility in clinical isolates.

Increased power from bacterial genome-wide association conditional on known effects identifies Neisseria gonorrhoeae macrolide resistance mutations in the 50S ribosomal protein L4

This study uses conditional GWAS to identify a new azithromycin resistance mutation in Neisseria gonorrhoeae, demonstrating its prevalence and geographic spread.

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

The paper identifies RNA polymerase mutations in Neisseria gonorrhoeae that confer ceftriaxone resistance independently of penA mutations.

Signatures of selection at drug resistance loci in Mycobacterium tuberculosis

This study analyzes drug resistance loci in Mycobacterium tuberculosis using whole genome sequencing to identify signatures of selection and novel resistance variants.

Adaptation in a fibronectin binding autolysin of Staphylococcus saprophyticus

The paper identifies a mutation in the aas gene of Staphylococcus saprophyticus that may enhance its ability to colonize the urinary tract, contributing to its pathogenicity.

Evolutionary thrift: mycobacteria repurpose plasmid diversity during adaptation of type VII secretion systems

This study investigates how mycobacteria repurpose plasmid diversity to adapt their type VII secretion systems through evolutionary mechanisms.