Author

K. C. Ma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:statistical model· 7 Organism:human· 6 Assay:whole-genome sequencing· 5 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Y. H. Grad· 7 shared T. D. Mortimer· 5 shared A. L. Hicks· 2 shared D. H. Rubin· 2 shared L. Sanchez-Buso· 2 shared N. E. Wheeler· 2 shared V. Eldholm· 2 shared A. Hirabayashi· 1 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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7 shared papersMicrobiology

Y. H. Grad

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Variation in supplemental carbon dioxide requirements defines lineage-specific antibiotic resistance acquisition in Neisseria gonorrhoeae

D. H. Rubin, K. C. Ma, K. A. Westervelt, K. Hullahalli, M. K. Waldor, Y. H. Grad

This study shows that metabolic variation in Neisseria gonorrhoeae, specifically CO2 dependence linked to a beta-carbonic anhydrase mutation, influences the likelihood of acquiring ciprofloxacin resistance.

bioRxiv · Feb 24, 2022 · PreprintMicrobiology

Loci for prediction of penicillin and tetracycline susceptibility in Neisseria gonorrhoeae: a genome wide association study

T. D. Mortimer, J. J. Zhang, K. C. Ma, Y. H. Grad

This study identifies two chromosomal loci, penA_01 and rpsJ codon 57, along with plasmid loci blaTEM and tetM, that predict penicillin and tetracycline susceptibility in Neisseria gonorrhoeae with high specificity.

bioRxiv · Aug 3, 2021Microbiology

Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae

K. Yahara, K. C. Ma, T. D. Mortimer, K. Shimuta, S.-i. Nakayama, A. Hirabayashi, M. Suzuki, M. Jinnai, H. Ohya, T. Kuroki, Y. Watanabe, M. Yasuda, T. Deguchi, V. Eldholm, O. B. Harrison, , M. Ohnishi

This study traces the emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae by analyzing genome sequences from multiple countries and time periods, revealing recombination events and antibiotic-driven mutations.

bioRxiv · Oct 26, 2020Microbiology

Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

K. C. Ma, T. D. Mortimer, A. L. Hicks, N. E. Wheeler, L. Sanchez-Buso, D. Golparian, G. Taiaroa, D. H. Rubin, Y. Wang, D. A. Williamson, M. Unemo, S. R. Harris, Y. H. Grad

This study identifies loss-of-function mutations in efflux pumps as a mechanism for increased antibiotic susceptibility in Neisseria gonorrhoeae cervical isolates.

Nature Communications · Aug 17, 2020Peer-reviewedMicrobiology

Efflux pump antibiotic binding site mutations are associated with azithromycin nonsusceptibility in clinical Neisseria gonorrhoeae isolates

K. C. Ma, T. D. Mortimer, Y. H. Grad

The study confirms that specific MtrD efflux pump mutations in Neisseria gonorrhoeae are linked to increased azithromycin nonsusceptibility in clinical isolates.

bioRxiv · Jun 3, 2020Microbiology

High-frequency phase-switching of modB methylase is associated with phenotypic ceftriaxone susceptibility in Neisseria gonorrhoeae

O. B. Brynildsrud, M. N. Osnes, K. C. Ma, Y. H. Grad, M. Koomey, D. A. Caugant, V. Eldholm

The paper shows high-frequency phase-switching of modB methylase in Neisseria gonorrhoeae is linked to decreased ceftriaxone susceptibility.

bioRxiv · Apr 13, 2020 · PreprintMicrobiology

Increased power from bacterial genome-wide association conditional on known effects identifies Neisseria gonorrhoeae macrolide resistance mutations in the 50S ribosomal protein L4

K. C. Ma, T. D. Mortimer, M. A. Duckett, A. L. Hicks, N. E. Wheeler, L. Sanchez-Buso, Y. H. Grad

This study uses conditional GWAS to identify a new azithromycin resistance mutation in Neisseria gonorrhoeae, demonstrating its prevalence and geographic spread.

bioRxiv · Mar 24, 2020Microbiology