Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein
K. Gaffney, R. Guo, M. D. Bridges, D. Chen, S. Muhammednazaar, M. Kim, Z. yang, A. L. Schilmiller, N. F. Faruk, X. Peng, A. D. Jones, L. Sun, W. L. Hubbell, T. Sosnick, H. Hong
This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.
bioRxiv · May 17, 2021Biophysics