H. Hong

Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression

The paper uses spatial transcriptomics and single-cell RNA sequencing to identify cellular organization patterns and immune microenvironment changes in early lung adenocarcinoma progression.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

This study identifies tissue- and subset-specific roles of SLC38A1 in Th1 cell function during inflammation, showing its importance in EAE and IBD but not lung inflammation.

Theranostic Bottle-Brush Polymers Tailored for Universal Solid-Tumour Targeting

This study develops bottle-brush polymers optimized for tumour targeting, showing improved delivery efficacy and reduced toxicity in various tumour models.

Small extracellular vesicles promote stiffness-mediated metastasis

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins

This study shows that lipid bilayers enhance membrane protein stability and their response to external stimuli by influencing hydrophobic thickness and amphiphile packing.

GPR4 knockout attenuates intestinal inflammation and forestalls the development of colitis-associated colorectal cancer in murine models

This study shows GPR4 knockout reduces intestinal inflammation and tumor development in colitis-associated colorectal cancer mouse models.

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

Balance-directed protein engineering of IsPETase enhances both PET hydrolysis activity and thermostability

This study engineers IsPETase to balance PET hydrolysis activity and thermostability, resulting in a variant that outperforms existing variants in depolymerization efficiency.

A MICROFLUIDIC DEVICE FOR LONG-TERM MAINTENANCE OF ORGANOTYPIC LIVER CULTURES

This paper introduces a microfluidic device that maintains organotypic liver cultures for up to 31 days, demonstrating sustained function and metabolic activity compared to traditional 96-well plate cultures.

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

Bioactive Hydrogel Microcapsules for Guiding Stem Cell Fate Decisions by Release and Reloading of Growth Factors

This paper develops bioactive microcapsules to guide hPSC fate by releasing and reloading growth factors, reducing GF usage and improving differentiation outcomes.

Balancing growth amidst salinity stress-lifestyle perspectives from the extremophyte model Schrenkiella parvula

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

A non-enzymatic acetylation of lysine residues adversely affects the Rubisco activase protein stability

This study shows that non-enzymatic acetylation of lysine residues in Rubisco activase reduces its stability and ATPase activity under varying light and heat stress conditions.

A framework for predicting potential host ranges of pathogenic viruses based on receptor ortholog analysis

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

MicroRNA-214 prevents pulmonary angiogenesis and alveolarization in rat models with hyperoxia-mediated impairment of lung development by blocking PlGF-dependent STAT3 signaling pathway

This study shows miR-214 reduces pulmonary angiogenesis and alveolarization in BPD by inhibiting PlGF and STAT3 signaling in hyperoxic rat models.

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors

This study investigates how HMGB1 and RAGE promote tumor growth in autophagy-deficient livers by altering the tumor microenvironment and mitochondrial function.

TDAG8 (GPR65) Inhibits Intestinal Inflammation in the DSS-Induced Experimental Colitis Mouse Model

This study shows that TDAG8 inhibits intestinal inflammation in a DSS-induced colitis mouse model, with implications for IBD treatment.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

This study shows macrophages in pancreatic cancer release pyrimidines that inhibit gemcitabine therapy by competing with the drug for uptake and metabolism, and reducing macrophage burden improves treatment response.