Author

W. L. Hubbell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Hong· 2 shared M. D. Bridges· 2 shared M. Kim· 2 shared R. Guo· 2 shared S. Muhammednazaar· 2 shared A. D. Jones· 1 shared A. El Daibani· 1 shared A. L. Schilmiller· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

H. Hong

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins

S. Muhammednazaar, J. Yao, M. R. Nicelis, Y. C. Park, Z. Shen, M. D. Bridges, R. Guo, N. Swope, M. S. Rhee, M. Kim, K. H. Kim, W. L. Hubbell, K. G. Fleming, L. Columbus, S.-g. Kang, H. Hong

This study shows that lipid bilayers enhance membrane protein stability and their response to external stimuli by influencing hydrophobic thickness and amphiphile packing.

bioRxiv · May 30, 2023Biophysics

Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy

J. Zhao, M. Elgeti, E. O'Brien, C. Sar, A. El Daibani, J. Heng, X. Sun, T. Che, W. L. Hubbell, B. Kobilka, C. Chen

The paper uses biophysical techniques to show how ligand-induced conformational changes in the μ-opioid receptor affect its signaling efficacy.

bioRxiv · Apr 28, 2023 · PreprintBiochemistry

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

K. Gaffney, R. Guo, M. D. Bridges, D. Chen, S. Muhammednazaar, M. Kim, Z. yang, A. L. Schilmiller, N. F. Faruk, X. Peng, A. D. Jones, L. Sun, W. L. Hubbell, T. Sosnick, H. Hong

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

bioRxiv · May 17, 2021Biophysics