Author

M. D. Bridges

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Hong· 2 shared M. Kim· 2 shared R. Guo· 2 shared S. Muhammednazaar· 2 shared W. L. Hubbell· 2 shared Z. Yang· 2 shared A. D. Jones· 1 shared A. Escolano· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

H. Hong

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Author profile →

3 papers

Recent·Most cited

Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins

S. Muhammednazaar, J. Yao, M. R. Nicelis, Y. C. Park, Z. Shen, M. D. Bridges, R. Guo, N. Swope, M. S. Rhee, M. Kim, K. H. Kim, W. L. Hubbell, K. G. Fleming, L. Columbus, S.-g. Kang, H. Hong

This study shows that lipid bilayers enhance membrane protein stability and their response to external stimuli by influencing hydrophobic thickness and amphiphile packing.

bioRxiv · May 30, 2023Biophysics

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Z. Yang, K.-M. A. Dam, M. D. Bridges, M. A. G. Hoffmann, A. T. DeLaitsch, H. B. Gristick, A. Escolano, R. Gautam, M. A. Martin, M. Nussenzweig, W. Hubbell, P. J. Bjorkman

This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.

bioRxiv · Nov 2, 2021Immunology

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

K. Gaffney, R. Guo, M. D. Bridges, D. Chen, S. Muhammednazaar, M. Kim, Z. yang, A. L. Schilmiller, N. F. Faruk, X. Peng, A. D. Jones, L. Sun, W. L. Hubbell, T. Sosnick, H. Hong

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

bioRxiv · May 17, 2021Biophysics