N. H. Davies

In silico mechanics of stem cells intramyocardially transplanted with a biomaterial injectate for treatment of myocardial infarction

This study uses finite element models to analyze how biomaterial stiffness affects stem cell deformation in a rat heart after myocardial infarction.

Mathematical Model of Mechanosensing and Mechanically Induced Collective Motility of Cells on Planar Elastic Substrates

This paper develops a mathematical model to simulate mechanically-induced collective cell motility on elastic substrates and demonstrates its predictive capabilities for wound closure and cell behavior.

Effect of biomaterial stiffness on cardiac mechanics in a biventricular infarcted rat heart model with microstructural representation of in situ intramyocardial injectate

This study develops a biventricular finite element model of an infarcted rat heart with microstructural biomaterial injectate to investigate how stiffness affects cardiac mechanics.

Effect of paclitaxel treatment on cellular mechanics and morphology of human oesophageal squamous cell carcinoma in 2D and 3D environments

This study examines how paclitaxel affects the stiffness and morphology of human oesophageal squamous cell carcinoma cells in 2D and 3D environments, finding increased stiffness in 2D but mixed results in 3D.

In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in membrane for uniaxial substrate stretch

The paper assesses how stress fibre content and substrate stiffness affect strain distribution in different cell regions using a finite element model.

Micromechanical homogenisation of a hydrogel-filled electrospun scaffold for tissue-engineered epicardial patching of the infarcted heart

This paper uses homogenization techniques to model the mechanical properties of a hydrogel-filled scaffold for cardiac tissue engineering and predicts its impact on ventricular function.

Tissue ingrowth markedly reduces mechanical anisotropy and stiffness in fibre direction of highly aligned electrospun polyurethane scaffolds

This study examines how tissue ingrowth affects the mechanical properties of electrospun polyurethane scaffolds, finding reduced stiffness in the fiber direction and increased stiffness transversely.

Electrospun polyester-urethane scaffold preserves mechanical properties and exhibits strain stiffening during in situ tissue ingrowth and degradation

This study compares biostable and degradable electrospun polyester-urethane scaffolds, showing that the degradable scaffold maintains consistent mechanical properties after 14 days of in vivo implantation.

Identification of orthotropic material parameters for acute, necrotic, fibrotic and remodelling myocardial infarcts in the rat

This study identifies orthotropic material parameters for different stages of myocardial infarcts in rats using inverse finite element methods and genetic algorithms.