T. Franz

A constitutive model for the remodelling erythrocyte membrane skeleton during the active invasion by the malaria merozoite

This paper develops a constitutive model to simulate erythrocyte membrane damage during malaria merozoite invasion, showing reduced membrane stiffness with increasing phosphorylation.

Mathematical model for force and energy of virion-cell interactions during full engulfment in HIV: Impact of virion maturation and host cell morphology

This study develops a mathematical model to quantify virion-cell interactions during HIV engulfment, showing that localized membrane features and maturation affect viral entry.

In silico mechanics of stem cells intramyocardially transplanted with a biomaterial injectate for treatment of myocardial infarction

This study uses finite element models to analyze how biomaterial stiffness affects stem cell deformation in a rat heart after myocardial infarction.

Mathematical Model of Mechanosensing and Mechanically Induced Collective Motility of Cells on Planar Elastic Substrates

This paper develops a mathematical model to simulate mechanically-induced collective cell motility on elastic substrates and demonstrates its predictive capabilities for wound closure and cell behavior.

An analytical model describing the mechanics of erythrocyte membrane wrapping during active invasion of a plasmodium falciparum merozoite

This study develops a mathematical model to describe the mechanical forces and deformations during Plasmodium falciparum merozoite invasion of erythrocytes, showing how membrane phosphorylation reduces indentation work.

Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments

This study shows that melanoma cell spreading in 3D environments depends on both cell stiffness and TBX3 expression, with different behaviors observed in soft versus stiff matrices.

Effect of biomaterial stiffness on cardiac mechanics in a biventricular infarcted rat heart model with microstructural representation of in situ intramyocardial injectate

This study develops a biventricular finite element model of an infarcted rat heart with microstructural biomaterial injectate to investigate how stiffness affects cardiac mechanics.

Effect of paclitaxel treatment on cellular mechanics and morphology of human oesophageal squamous cell carcinoma in 2D and 3D environments

This study examines how paclitaxel affects the stiffness and morphology of human oesophageal squamous cell carcinoma cells in 2D and 3D environments, finding increased stiffness in 2D but mixed results in 3D.

In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in membrane for uniaxial substrate stretch

The paper assesses how stress fibre content and substrate stiffness affect strain distribution in different cell regions using a finite element model.

An exploratory study on the role of the stiffness of breast cancer cells in their detachment from spheroids and migration in 3D collagen matrices

This study investigates how breast cancer cell stiffness changes during detachment from spheroids and migration in 3D collagen matrices, finding that decreased stiffness facilitates detachment and migration.

Micromechanical homogenisation of a hydrogel-filled electrospun scaffold for tissue-engineered epicardial patching of the infarcted heart

This paper uses homogenization techniques to model the mechanical properties of a hydrogel-filled scaffold for cardiac tissue engineering and predicts its impact on ventricular function.

Tissue ingrowth markedly reduces mechanical anisotropy and stiffness in fibre direction of highly aligned electrospun polyurethane scaffolds

This study examines how tissue ingrowth affects the mechanical properties of electrospun polyurethane scaffolds, finding reduced stiffness in the fiber direction and increased stiffness transversely.

Cytoskeletal Tubulin Competes with Actin to Increase Deformability of Metastatic Melanoma Cells

This study shows that metastatic melanoma cells have increased fluidity and cytoskeletal components, which enhance motility while reducing stiffness compared to earlier disease stages.

Electrospun polyester-urethane scaffold preserves mechanical properties and exhibits strain stiffening during in situ tissue ingrowth and degradation

This study compares biostable and degradable electrospun polyester-urethane scaffolds, showing that the degradable scaffold maintains consistent mechanical properties after 14 days of in vivo implantation.

Identification of orthotropic material parameters for acute, necrotic, fibrotic and remodelling myocardial infarcts in the rat

This study identifies orthotropic material parameters for different stages of myocardial infarcts in rats using inverse finite element methods and genetic algorithms.