G. Higgins

Identification of Lactuca sativa transcription factors impacting resistance to Botrytis cinerea through predictive network inference

The paper identifies transcription factors in lettuce that influence resistance to Botrytis cinerea by inferring gene regulatory networks from time-series expression data.

Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments

This study shows that melanoma cell spreading in 3D environments depends on both cell stiffness and TBX3 expression, with different behaviors observed in soft versus stiff matrices.

Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens

The paper identifies genetic loci in lettuce conferring quantitative resistance to fungal pathogens and predicts molecular mechanisms through transcriptome profiling.

Effect of paclitaxel treatment on cellular mechanics and morphology of human oesophageal squamous cell carcinoma in 2D and 3D environments

This study examines how paclitaxel affects the stiffness and morphology of human oesophageal squamous cell carcinoma cells in 2D and 3D environments, finding increased stiffness in 2D but mixed results in 3D.

An exploratory study on the role of the stiffness of breast cancer cells in their detachment from spheroids and migration in 3D collagen matrices

This study investigates how breast cancer cell stiffness changes during detachment from spheroids and migration in 3D collagen matrices, finding that decreased stiffness facilitates detachment and migration.

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

This study identifies SUMO-1 modification of DNA-protein crosslinks (DPCs) as a mechanism that promotes SPRTN proteolysis over homologous recombination, preventing genomic instability.

Cytoskeletal Tubulin Competes with Actin to Increase Deformability of Metastatic Melanoma Cells

This study shows that metastatic melanoma cells have increased fluidity and cytoskeletal components, which enhance motility while reducing stiffness compared to earlier disease stages.

Pseudomonas aeruginosa PA5oct jumbo phage impacts planktonic and biofilm population and reduces its host virulence

This paper investigates the impact of jumbo phage PA5oct on P. aeruginosa populations and virulence, finding that it reduces bacterial numbers and virulence while persisting in resistant clones.