Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans
F. G. S. Silao, K. Ryman, T. Jiang, M. Ward, N. Hansmann, N.-N. Liu, C. Chen, P. O. Ljungdahl
This study shows that Gdh2-dependent alkalization is not required for C. albicans to escape macrophages or maintain virulence, challenging the existing model of amino acid catabolism in phagosomes.
bioRxiv · Jan 20, 2020Microbiology