F. G. S. Silao

This study identifies Gdh2 and its regulatory mechanisms in Candida albicans for amino acid-dependent environmental alkalization, showing its role in virulence and microbial community dynamics.

This study shows that proline catabolism is essential for Candida albicans pathogenicity, as mutations in proline utilization genes reduce virulence in animal models.

This study shows that Gdh2-dependent alkalization is not required for C. albicans to escape macrophages or maintain virulence, challenging the existing model of amino acid catabolism in phagosomes.

This study shows that mitochondrial proline metabolism via PUT1 and PUT2 enhances ATP production, activates the Ras1/cAMP/PKA pathway, and promotes filamentation in C. albicans, contributing to virulence.