Author

N. I. Lorenz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

M. W. Ronellenfitsch· 2 shared A. Lesur· 1 shared A. Oudin· 1 shared A.-L. Luger· 1 shared B. Sauer· 1 shared C. Jaeger· 1 shared C. Münch· 1 shared C. Pulido· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. W. Ronellenfitsch

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2 papers

Recent·Most cited

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

M. Benzarti, A. Oudin, E. Viry, E. Gargiulo, M. Schmoetten, L. Neises, C. Pulido, N. I. Lorenz, M. W. Ronellenfitsch, D. Sumpton, M. Warmoes, C. Jaeger, A. Lesur, J. Paggetti, E. Moussay, , J. Meiser

This study reveals that PKM2 inhibition redirects glycolytic and glutamine carbons into distinct metabolic pathways, supporting cancer cell metabolic flexibility under glycolytic limitation.

bioRxiv · Jan 23, 2023Cancer Biology

AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment

N. I. Lorenz, B. Sauer, P. S. Zeiner, M. I. Strecker, A.-L. Luger, D. Schulte, M. Mittelbronn, T. Alekseeva, L. Sevenich, P. N. Harter, C. Münch, J. P. Steinbach, M. W. Ronellenfitsch

This study shows that AMPK is essential for glioblastoma cells to adapt to low energy conditions in the tumor microenvironment, with AMPK inhibition reducing tumor growth and mitochondrial function.

bioRxiv · Mar 25, 2022 · PreprintCancer Biology