Author

M. Mittelbronn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Golebiewska· 2 shared A. Michelucci· 2 shared A. Muller· 2 shared A. Oudin· 2 shared A. Skupin· 2 shared B. Klink· 2 shared F. Hertel· 2 shared J.-J. Gerardy· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. Golebiewska

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

L. Bonetti, V. Horkova, J. Longworth, L. Guerra, H. Kurniawan, D. G. Franchina, L. Soriano-Baguet, M. Grusdat, S. Spath, E. Koncina, A. Ewen, C. Binsfeld, C. Verscheuren, J.-J. Gerardy, T. Kobayashi, , D. Brenner

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

bioRxiv · Jul 6, 2023Immunology

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

Y. A. Yabo, P. M. Moreno-Sanchez, Y. Pires-Afonso, T. Kaoma, B. Nosirov, A. Scafidi, L. Ermini, A. Lipsa, A. Oudin, D. Kyriakis, K. Grzyb, S. K. Poovathingal, A. Poli, A. Muller, R. Toth, , A. Golebiewska

This study characterizes the tumor microenvironment in glioblastoma patient-derived xenografts and patient tumors, revealing phenotypic heterogeneity in microglia and their functional adaptations.

bioRxiv · Mar 5, 2023Cancer Biology

AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment

N. I. Lorenz, B. Sauer, P. S. Zeiner, M. I. Strecker, A.-L. Luger, D. Schulte, M. Mittelbronn, T. Alekseeva, L. Sevenich, P. N. Harter, C. Münch, J. P. Steinbach, M. W. Ronellenfitsch

This study shows that AMPK is essential for glioblastoma cells to adapt to low energy conditions in the tumor microenvironment, with AMPK inhibition reducing tumor growth and mitochondrial function.

bioRxiv · Mar 25, 2022 · PreprintCancer Biology

Mucin-degrading gut bacteria promote anti-parasitic immunity

M. Wolter, M. Boudaud, E. Grant, A. Parrish, A. De Sciscio, S. Thompson, J.-J. Gerardy, M. Mittelbronn, D. J. Thornton, A. J. Macpherson, R. K. Grencis, M. S. Desai

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

bioRxiv · Feb 28, 2022 · PreprintImmunology

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

A. Golebiewska, A.-C. Hau, A. Oudin, D. Stieber, Y. A. Yabo, V. Baus, V. Barthelemy, E. Klein, S. Bougnaud, O. Keunen, M. Wantz, A. Michelucci, V. Neirinckx, A. Muller, T. Kaoma, , S. P. Niclou

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

bioRxiv · Apr 24, 2020Cancer Biology