Structure of SARS-CoV-2 2'-O-methyltransferase heterodimer with RNA Cap analog and sulfates bound reveals new strategies for structure-based inhibitor design
M. Rosas-Lemus, G. Minasov, L. Shuvalova, N. Inniss, O. Kiryukhina, J. Brunzelle, K. J. Satchell
The paper determines the structure of SARS-CoV-2 nsp16/nsp10 2'-O-methyltransferase complex with various ligands, identifying potential sites for antiviral inhibitor design.
Science Signaling · Sep 29, 2020Peer-reviewedMicrobiology