Author

O. Kiryukhina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:virus· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

G. MinasoviD· 2 shared K. J. Satchell· 2 shared L. ShuvalovaiD· 2 shared A. Godzik· 1 shared A. JoachimiakiD· 1 shared A. Wolfe· 1 shared E. V. Filippova· 1 shared G. Wiersum· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

G. MinasovORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure of SARS-CoV-2 2'-O-methyltransferase heterodimer with RNA Cap analog and sulfates bound reveals new strategies for structure-based inhibitor design

M. Rosas-Lemus, G. Minasov, L. Shuvalova, N. Inniss, O. Kiryukhina, J. Brunzelle, K. J. Satchell

The paper determines the structure of SARS-CoV-2 nsp16/nsp10 2'-O-methyltransferase complex with various ligands, identifying potential sites for antiviral inhibitor design.

Science Signaling · Sep 29, 2020Peer-reviewedMicrobiology

The crystal structure of nsp10-nsp16 heterodimer from SARS CoV-2 in complex with S-adenosylmethionine

M. Rosas Lemus, G. Minasov, L. Shuvalova, N. L. Inniss, O. Kiryukhina, G. Wiersum, Y. Kim, R. Jedrzejczak, N. I. Maltseva, M. Endres, L. Jaroszewski, A. Godzik, A. Joachimiak, K. J. Satchell

The paper determines the crystal structure of the SARS-CoV-2 nsp10-nsp16 heterodimer complex with S-adenosylmethionine at 1.80 Å resolution, revealing its role in viral mRNA capping and immune evasion.

bioRxiv · Apr 17, 2020 · PreprintBiochemistry

The spermidine acetyltransferase SpeG regulates transcription of the small RNA RprA

L. I. Hu, E. V. Filippova, J. Dang, S. Pshenychnyi, J. Ruan, O. Kiryukhina, W. F. Anderson, M. L. Kuhn, A. Wolfe

This study shows that SpeG, an acetyltransferase, interacts with RcsB to inhibit rprA transcription in E. coli, linking polyamine metabolism to global regulatory functions.

bioRxiv · Nov 5, 2018Microbiology