R. A. Cross

Taxol acts differently on different tubulin isotypes

This study shows taxol stabilizes human and zebrafish 1β4 microtubules more effectively than 1β3, causing conformational changes detectable by kinesin-driven gliding.

Coupled yawing and orbital rotation in kinesin motility revealed by polarization measurement of gold nanorods

This study uses gold nanorods to measure rotational motion in kinesin motors, revealing biaxial rotation that aids in navigating obstacles.

Force generation of KIF1C is impaired by pathogenic mutations

This study investigates the force generation of KIF1C and shows that pathogenic mutations impair its ability to generate force, leading to neuronal dysfunction.

Backstepping mechanism of kinesin-1

This paper proposes that all kinesin-1 backsteps are slips rather than steps, supported by experimental observations of timing differences and load-dependent behavior.

Activation of cytoplasmic dynein through microtubule crossbridging

This study shows that cytoplasmic dynein can crossbridge microtubules, enabling it to slide and polarity-sort microtubule bundles without requiring dynactin or cargo adapters.

Stabilising and destabilising kinesin complexes queue at plus tips to ensure microtubule catastrophe at cell ends

The paper shows that competition between stabilizing and destabilizing kinesin complexes at microtubule plus tips regulates iMT length in fission yeast.

Structural-mechanical remodelling of GDP-microtubules by kinesin

This study shows that kinesin-1 motor domains inhibit GDP-microtubule shrinkage and expand lattice spacing, revealing a new mechanochemical mechanism linking kinesin and tubulin.

Single molecule mechanics reveal Kif15 as an active molecular ratchet with acute strain sensitivity

This study investigates the single molecule mechanics of Kif15, revealing its strain sensitivity and directional load-dependent behavior.