Author

N. J. Dusetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. Nicolle· 4 shared J. Iovanna· 3 shared J. L. IOVANNA· 3 shared J. Roques· 3 shared O. Gayet· 3 shared C. Neuzillet· 2 shared J. Cros· 2 shared J. Raffenne· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

R. Nicolle

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6 papers

Recent·Most cited

Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom-up approach

M. Hilmi, F. Delecourt, J. Raffenne, T. Bourega, N. J. Dusetti, J. Iovanna, Y. Blum, M. Richard, C. Neuzillet, A. Couvelard, L. De Mestier, V. Rebours, R. Nicolle, J. Cros

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.

bioRxiv · Nov 16, 2023Cancer Biology

Metabolomic profiling of pancreatic adenocarcinoma reveals fundamental clinical features

J. L. IOVANNA, A. El kaoutari, N. Fraunhoffer, O. Hoare, C. Teyssedou, O. Gayet, J. Roques, G. A. Lomberk, R. A. Urrutia, N. J. Dusetti

This study identifies a metabolic signature in pancreatic adenocarcinoma that predicts clinical outcomes and drug resistance, suggesting metabolic targeting as a therapeutic strategy.

bioRxiv · Feb 1, 2021Cancer Biology

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer.

S. Shin, R. Nicolle, C. Jean, R. Samain, M. Ayadi, J. Raffenne, A. Brunel, J. Solorzano, C. Neuzillet, C. Joffre, S. Rocchi, J. Iovanna, N. J. Dusetti, O. Larsson, S. Pyronnet, , Y. Martineau

The paper identifies a new pancreatic cancer subtype with low protein synthesis but high integrated stress response activation, linked to metabolic impairments and drug resistance.

bioRxiv · Dec 23, 2020Cancer Biology

E-cadherin is a structuring component of invadopodia in pancreatic cancer

A. Dobric, S. Germain, F. Silvy, R. Bonier, S. Audebert, L. Camoin, N. J. Dusetti, P. Soubeyran, J. Iovanna, V. Rigot, F. Andre

This study identifies E-cadherin as a critical structural component of invadopodia in pancreatic cancer cells, showing its role in invadopodia formation and structuration through interactions with Arp2/3, Cortactin, and MT1-MMP.

bioRxiv · Oct 9, 2020Cancer Biology

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

R. Nicolle, Y. Blum, P. Duconseil, C. Vanbrugghe, N. Brandone, F. Poizat, J. Roques, M. Bigonnet, O. Gayet, M. Rubis, N. Elarouci, L. Armenoult, M. Ayadi, A. Dereynies, M. Giovannini, , N. J. Dusetti

This paper develops a transcriptomic gradient (PAMG) to predict pancreatic cancer aggressiveness and treatment response using patient-derived xenografts and clinical data.

bioRxiv · Mar 25, 2020Cancer Biology

Basal-like and Classical cells coexistence in pancreatic cancer revealed by single cell analysis

N. J. Dusetti, N. Juiz, A. Elkaoutari, M. Bigonnet, O. Gayet, J. Roques, R. Nicolle, J. L. Iovanna

The paper uses single-cell transcriptomic analysis to show that basal-like and classical cells coexist in pancreatic cancer tumors, revealing unexpected heterogeneity.

bioRxiv · Jan 7, 2020Cancer Biology