J. Cros

An angiosperm-wide perspective on reproductive strategiesand floral traits

The paper analyzes floral and reproductive traits across 361 flowering plant species to show that dioecy is linked to floral traits, while correlations with lifespan and dispersal are spurious.

Self-supervised learning to predict intrahepatic cholangiocarcinoma transcriptomic classes on routine histology

This paper develops a self-supervised learning model to predict iCCA transcriptomic classes from histological images, achieving good to very good performance in multiple validation sets.

Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom-up approach

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

PACpAInt uses deep learning to identify molecular subtypes of pancreatic adenocarcinoma on histology slides, revealing prognostic heterogeneity and novel subtypes.

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

This paper develops a transcriptomic gradient (PAMG) to predict pancreatic cancer aggressiveness and treatment response using patient-derived xenografts and clinical data.