S. Shin

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

This study shows that deleting Rbpj in hepatic progenitor cells reduces fibrosis and endothelial responses in DDC-fed mice by downregulating VCAM1 expression.

The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

This study reconstructs the evolutionary history of Belidae weevils to show how their host plant shifts and dispersal were influenced by Gondwana breakup and angiosperm rise.

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

WildPose: A Long-Range 3D wildlife motion capture system

WildPose enables long-range 3D motion capture of wildlife for ecological and biomechanical studies, demonstrating accurate tracking and morphological analysis in field trials.

RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism

The paper shows RNA G-quadruplexes regulate mitochondrial function by modulating cytoplasmic mRNA translation of nuclear-encoded mitochondrial proteins, impacting energy metabolism and cancer cell proliferation.

A comprehensive landscape of the zinc-regulated human proteome

This study maps zinc-regulated cysteine sites in the human proteome, identifies cancer dependencies, and reveals a mechanism of zinc-induced cytotoxicity in lung cancers.

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2

This study identifies infection-enhancing antibodies targeting the N-terminal domain of SARS-CoV-2 spike protein, which persist in convalescent patients and may be counteracted by viral mutations.

Characterization of SARS-CoV-2 Convalescent Patients' Serological Repertoire Reveals High Prevalence of Iso-RBD Antibodies

This study characterizes the serological repertoire of SARS-CoV-2 convalescent patients, revealing a high prevalence of iso-RBD antibodies that do not recognize prefusion-stabilized S, and shows that vaccination with prefusion-stabilized S reduces their prevalence.

Highly effective gene inactivation in tetraploid Xenopus laevis with low-temperature-active engineered Cas12a

This study evaluates engineered Cas12a variants for gene inactivation in Xenopus laevis, finding that Cas12a-Ultra achieves high efficiency at low temperatures.

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

This study identifies caspase-1 and GSDMD as key mediators of inflammasome responses that restrict Salmonella replication in human macrophages.

TNF and type I IFN induction of the IRG1-itaconate pathway restricts Coxiella burnetiireplication within mouse macrophages

This study shows TNF and type I IFN induce the IRG1-itaconate pathway to restrict C. burnetii replication in mouse macrophages.

Diffusiophoresis promotes phase separation and transport of biomolecular condensates

This study shows ion gradients drive diffusiophoresis, enhancing transport and phase separation of biomolecular condensates through active motility and redistribution.

Blockade of IKK signaling induces RIPK1-independent apoptosis in human cells

This study shows that IKK blockade induces RIPK1-independent apoptosis in human cells, contrasting with murine models where RIPK1 is required.

Nuclear cytoglobin associates with HMGB2 and regulates DNA damage and genome-wide transcriptional output in the vasculature

This study identifies nuclear cytoglobin's role in regulating DNA damage and transcriptional output in vascular smooth muscle cells through its interaction with HMGB2.

A TNF-IL-1 circuit controls Yersinia within intestinal granulomas

This study identifies a monocyte-intrinsic TNF-IL-1 circuit that controls Yersinia infection within intestinal granulomas by signaling to non-hematopoietic cells.

Gelation of Uniform Interfacial Diffusant in Embedded 3D Printing

This paper introduces a 3D bioprinting method called GUIDE-3DP to create perfusable, branched vascular networks with precise control over geometry and vessel sizes.

A method for extracting effective interactions from Hi-C data with applications to interphase chromosomes and inverted nuclei

This paper introduces a method to extract effective interaction energies from Hi-C data to model chromosome organization, showing that heterochromatin attraction drives compartment formation in conventional and inverted nuclei.

The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases

This study identifies that the tetrapeptide sequence of IL-1β regulates its cleavage by non-canonical inflammasomes, revealing a mechanism for inflammation control.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Yersinia Type III-Secreted Effectors Evade the Caspase-4 Inflammasome in Human Cells

This study shows Yersinia pseudotuberculosis effectors evade the caspase-4 inflammasome in human cells, unlike in mouse macrophages, by inhibiting Yersinia internalization.

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

Mesenchymal Progenitors set the homeostatic inflammatory milieu via the TAK1-NFkB axis.

This study shows mesenchymal progenitors regulate the balance between type 1 and type 2 inflammation via the TAK1-NFkB pathway, with implications for inflammatory diseases.

Fusion of Video and Inertial Sensing Data via Dynamic Optimization of a Biomechanical Model

This study fuses RGB video and inertial sensing data using a dynamically constrained biomechanical model, showing improved motion tracking accuracy compared to single-modality and unconstrained fusion methods.

Reduction of RBD Binding Affinity to Glycosylated ACE2 is Entropic in Origin

The paper develops a lattice model to test if entropic forces from ACE2 glycans affect RBD binding, finding that glycans have a weak entropic effect.

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular autoprocessing

This study shows that Casp11 catalytic activity and autoprocessing are required for noncanonical inflammasome assembly and LPS-induced speck formation in macrophages.

Infant antibody repertoires during the first two years of influenza vaccination

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts Legionella pneumophila infection

This study shows TNF enables macrophages to undergo rapid caspase-mediated cell death, which restricts Legionella pneumophila infection.

Hybrid immunity shifts the Fc-effector quality of SARS-CoV-2 mRNA vaccine-induced immunity

This study compares the humoral immune response in individuals with and without prior COVID-19 after mRNA vaccination, finding that hybrid immunity enhances Fc-effector quality rather than quantity.

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.