A two-hit epistasis model prevents core genome disharmony in recombining bacteria
A. J. Taylor, K. Yahara, B. Pascoe, L. Mageiros, E. Mourkas, J. K. Calland, S. Puranen, M. D. Hitchings, K. A. Jolley, C. M. Kobras, S. C. Bayliss, N. J. Williams, A. H. van Vliet, J. Parkhill, M. C. Maiden, , S. K. Sheppard
The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.
bioRxiv · Mar 15, 2021 · PreprintMicrobiology