Author

S. K. Sheppard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Assay:whole-genome sequencing· 5 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2

Frequent Co-Authors

B. Pascoe· 7 shared J. K. Calland· 6 shared M. D. Hitchings· 6 shared E. Mourkas· 5 shared G. Meric· 3 shared J. Corander· 3 shared K. A. Jolley· 3 shared M. C. Maiden· 3 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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7 shared papersMicrobiology

B. Pascoe

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Genomic tailoring of autogenous poultry vaccines to reduce Campylobacter from farm to fork

J. K. Calland, M. E. Pesonen, J. Mehat, B. Pascoe, D. J. Haydon, J. Lourenco, E. Mourkas, M. D. Hitchings, R. M. LaRagione, P. Hammond, T. S. Wallis, J. Corander, S. K. Sheppard

This paper develops a genomic autogenous vaccine for poultry to reduce Campylobacter, showing reduced extra-intestinal survival genes and meat surface survival in vaccinated flocks.

bioRxiv · Nov 9, 2023 · PreprintMicrobiology

Local accessory gene sharing drives lineage-specific acquisition of antimicrobial resistance in Egyptian Campylobacter spp.

S. F. Mouftah, B. Pascoe, J. K. Calland, E. Mourkas, N. Tonkin, C. Lefevre, D. Deuker, S. Smith, H. Wickenden, M. D. Hitchings, S. K. Sheppard, M. Elhadidy

This study analyzes Campylobacter isolates from Egypt to show increased local accessory genome sharing in specific lineages, contributing to higher antimicrobial resistance in C. coli.

bioRxiv · Sep 24, 2021 · PreprintMicrobiology

Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter

E. Mourkas, K. Yahara, S. C. Bayliss, J. K. Calland, H. Johansson, L. Mageiros, Z. Y. Munoz-Ramirez, G. Futcher, G. Meric, M. D. Hitchings, S. Sandoval-Motta, J. Torres, K. A. Jolley, M. C. Maiden, P. Ellstrom, , S. K. Sheppard

The paper quantifies horizontal gene transfer (HGT) between Campylobacter species with different host ecologies, showing cohabitation in the same host increases HGT by 6-fold.

bioRxiv · Aug 24, 2021Microbiology

Non-serotype 2 isolates from healthy pigs are a potential zoonotic reservoir of Streptococcus suis genetic diversity and antimicrobial resistance

N. Kittiwan, J. K. Calland, E. Mourkas, M. D. Hitchings, S. Murray, P. Tadee, P. Tadee, K. Duangsonk, S. K. Sheppard, G. Meric, P. Patchanee, B. Pascoe

The paper identifies non-serotype 2 Streptococcus suis isolates from healthy pigs as a reservoir of genetic diversity and antimicrobial resistance, which may contribute to zoonotic transmission and treatment failure.

bioRxiv · Jun 17, 2021 · PreprintMicrobiology

A two-hit epistasis model prevents core genome disharmony in recombining bacteria

A. J. Taylor, K. Yahara, B. Pascoe, L. Mageiros, E. Mourkas, J. K. Calland, S. Puranen, M. D. Hitchings, K. A. Jolley, C. M. Kobras, S. C. Bayliss, N. J. Williams, A. H. van Vliet, J. Parkhill, M. C. Maiden, , S. K. Sheppard

The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.

bioRxiv · Mar 15, 2021 · PreprintMicrobiology

Multiple clones of colistin-resistant Salmonella enterica carrying mcr-1 plasmids in meat products and patients in Northern Thailand

P. Patchanee, N. Chokesajjawatee, P. Santiyanont, P. Chuammitri, M. Deeudom, W. Monteith, S. K. Sheppard, B. Pascoe, T. Prasertee

The paper identifies colistin-resistant Salmonella enterica clones carrying mcr-1 plasmids in meat and human cases in Northern Thailand, showing genetic relatedness between isolates.

bioRxiv · Dec 8, 2020Microbiology

Domestication of Campylobacter jejuni NCTC 11168

B. Pascoe, L. K. Williams, J. K. Calland, G. Meric, M. D. Hitchings, M. Dyer, J. Ryder, S. Shaw, B. S. Lopes, C. Chintoan-Uta, E. Allan, A. Vidal, C. Fearnley, P. Everest, J. A. Pachebat, , S. K. Sheppard

This study compares genetic and phenotypic variation in 23 isolates of the reference Campylobacter jejuni strain NCTC 11168, showing significant genomic and phenotypic differences despite being considered identical.

bioRxiv · Apr 18, 2019Microbiology

Weak epistasis may drive adaptation in recombining bacteria

B. J. Arnold, M. Gutmann, Y. Grad, S. K. Sheppard, J. Corander, M. Lipsitch, W. P. Hanage

This study shows that weak epistasis can influence adaptation in recombining bacteria, even when recombination is frequent, due to limited transfer of genetic segments.

bioRxiv · Mar 23, 2017Evolutionary Biology